Bow Foundation 2025 Grant LOI Application

The Bow Foundation will provide one-year grants to support research related to GNAO1 Neurodevelopmental Disorder. At least 2 awards will be granted at $100,000 each.

 Background

The Bow Foundation, in collaboration with the Orphan Disease Center, is seeking proposals to advance research related to GNAO1 Neurodevelopmental Disorder. We are looking for applications that aim to further progress our understanding of the disease, the available therapeutic options, and investigating strategies to establish outcome measurements. The RFA could focus on one, or several, of the following aims, to further advance GNAO1 research and therapeutic approaches:

• Novel therapeutic approaches, including, but not limited to, techniques in genome editing, RNA-based mechanisms, biologics, novel cell-based therapeutics, and development of novel therapeutic compounds, including through small molecule repurposing or screening against validated phenotypes in human cellular systems.

• Proposals that include collaboration across organizations or other rare diseases.

• Establishment of outcome measures for future clinical trials.

• Supporting pilot clinical trials, preclinical trials, or animal model trials that promote drug repurposing strategies.

• Other aims are welcome and will be considered.

At least 2 one-year grants for up to $100,000 each (total cost) will be awarded.

Eligibility

All individuals holding a faculty-level appointment at an academic institution or a senior position

at a non-profit institution or foundation are eligible to respond to this RFA.

Full Applications are Due Friday, February 14, 2025 by 8pm EST

To Apply:

Step 1: Please review the  RFA Guidelines.

Step 2: Apply through Submittable

For any scientific inquiries regarding this grant please email Deborah Requesens.

For any administrative inquiries regarding this grant please email Leslie Silverman.