Safety, Accuracy, and Feasibility of Continuous Glucose Monitoring in Infants in the Inpatient NICU Setting with Hyperinsulinism and Hypoglycemia

Awardee: Paul Thornton

Institution: Cook Children's Medical Center

Grant Amount: $77,165

Funding Period: February 1, 2025 - January 31, 2026


Summary:

Hyperinsulinism is a group of hypoglycemic disorders that may occur in newborns. Early detection and management are crucial as prolonged hypoglycemia can lead to neurological damage and developmental delays. Continuous glucose monitoring (CGM) offers a promising solution by providing the clinical team with a continuous trend of glucose concentration over time. This enables early detection of falling glucose levels and presents opportunities for timely intervention. Our goal is to assess the safety, accuracy, and feasibility of CGM in infants with hyperinsulinism in in-patient NICU settings. We will also use results from our study to improve data collection in the Hyperinsulinism registry by developing surveys about the use of CGM in a NICU setting and the parents’ experience and satisfaction with the CGM.

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Leveraging Human iPSC Derived Beta Cells to Investigate the Impact of Novel Therapeutics in Patients with Congenital Hyperinsulinism

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Tcf4 in gut development; investigating underlying causes of gastro-intestinal problems in patients with Pitt Hopkins syndrome