Elucidating a link between microfractures and fibrous dysplasia bone pain in mice

MDBRFDMAS
Written By Million Dollar Bike Ride

Awardee: Ariane Zamarioli

Institution: Ribeirao Preto Medical School

Grant Amount: $40,234.00

Funding Period: February 1, 2025 - January 31, 2026

Summary:

FD/MAS are severe congenital disorders that result in significant bone pain, skeletal deformities, and endocrine dysfunction. Bone pain is one of the most difficult symptoms to manage in FD/MAS patients. Currently, a variety of pharmacotherapies, including bisphosphonates, are used to alleviate skeletal disease activity and bone pain. However, the mechanisms behind bone pain in FD/MAS remain unclear. Microfractures are suspected to be a contributing factor. This proposal seeks to explore the relationship between FD-related bone pain and microfractures using an established FD animal model.

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Targeting GNAS-Driven Pathway for Precision Therapy of Fibrous Dysplasia
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